Resistance of Candida glabrata to drugs and the host immune system
نویسندگان
چکیده
منابع مشابه
resistance of candida albicans biofilms to drugs and the host immune system
conclusion mature biofilms were found to be much more resistant to antifungal agents and the host immune system than free cells. the factors responsible for high resistance included the complex architecture of biofilms, ecm, increased expression of drug efflux pumps, and metabolic plasticity. objectives the present work investigated certain aspects of the resistance of c. albicans biofilms to d...
متن کاملResistance of Candida albicans Biofilms to Drugs and the Host Immune System
BACKGROUND Candida albicans is a commensal fungus that resides on mucosal surfaces and in the gastrointestinal and genitourinary tracts in humans. However, it can cause an infection when the immune system of the host is impaired or if a niche becomes available. Many C. albicans infections are due to the organism's ability to form a biofilm on implanted medical devices. A biofilm represents an o...
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We report a case of infection with Candida glabrata in which the organism became resistant to fluconazole and in which pre- and posttreatment isolates were available for comparison. The organism was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Fluconazole was a potent inhibitor of cytochrome P-450-dependent 14 alpha-sterol demethylase (P-450DM) ...
متن کاملComparison of pathogenesis and host immune responses to Candida glabrata and Candida albicans in systemically infected immunocompetent mice.
Cytokine-mediated host defense against Candida glabrata infection was compared to that against C. albicans, using immunocompetent murine models of systemic candidiasis. The pathogenesis of infection was evaluated morphologically and by culture of target organs, while the kinetics of induction of cytokine mRNAs and corresponding proteins were determined in kidneys by real-time reverse transcript...
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The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species. We find that induction of conserved genes encoding antioxidant functions is dependent on the transcription factors CgYap1 and CgSkn7 which cooperate for promoter recognition. Superoxide stress resistance of C. glabrata is provided by superoxide dis...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infectious Diseases
سال: 2018
ISSN: 2398-8096
DOI: 10.15761/cmid.1000145